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- Title
Targeting the internal epitope of prostate-specific membrane antigen with 89Zr-7E11 immuno-PET.
- Authors
Ruggiero, Alessandro; Holland, Jason P; Hudolin, Tvrtko; Shenker, Larissa; Koulova, Anna; Bander, Neil H; Lewis, Jason S; Grimm, Jan
- Abstract
The potential of the positron-emitting (89)Zr has been recently investigated for the design of radioimmunoconjugates for immuno-PET. In this study, we report the preparation and in vivo evaluation of (89)Zr-desferrioxamine B (DFO)-7E11, a novel (89)Zr-labeled monoclonal antibody (mAb) construct for targeted imaging of prostate-specific membrane antigen (PSMA), a prototypical cell surface marker highly overexpressed in prostate cancer. The ability of (89)Zr-DFO-7E11 to delineate tumor response to therapy was also investigated, because it binds to the intracellular epitope of PSMA, which becomes available only on membrane disruption in dead or dying cells.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, Vol 52, Issue 10, p1608
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.111.092098