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- Title
Evaluation of a calibrated (18)F-FDG PET score as a biomarker for progression in Alzheimer disease and mild cognitive impairment.
- Authors
Herholz, Karl; Westwood, Sarah; Haense, Cathleen; Dunn, Graham
- Abstract
Increasingly, clinical trials are being planned in patients with mild cognitive impairment (MCI) to prevent or delay the onset of dementia in Alzheimer disease (AD) by disease-modifying intervention. Inclusion of imaging techniques as biomarkers for patient selection and assessment of outcome is expected to increase trial efficacy. PET using (18)F-FDG provides objective information about the impairment of synaptic function and could, with appropriate standardization, qualify as a biomarker.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, Vol 52, Issue 8, p1218
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.111.090902