We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Performance characteristics of amyloid PET with florbetapir F 18 in patients with alzheimer's disease and cognitively normal subjects.
- Authors
Joshi, Abhinay D; Pontecorvo, Michael J; Clark, Chrisopher M; Carpenter, Alan P; Jennings, Danna L; Sadowsky, Carl H; Adler, Lee P; Kovnat, Karel D; Seibyl, John P; Arora, Anupa; Saha, Krishnendu; Burns, Jason D; Lowrey, Mark J; Mintun, Mark A; Skovronsky, Daniel M; Florbetapir F 18 Study Investigators
- Abstract
The objectives of this study were to examine the effective dose range and the test-retest reliability of florbetapir F 18 using, first, visual assessment by independent raters masked to clinical information and, second, semiautomated quantitative measures of cortical target area to cerebellum standardized uptake value ratios (SUVr) as primary outcome measures. Visual ratings of PET image quality and tracer retention or β-amyloid (Aβ) binding expressed as SUVrs were compared after intravenous administration of either 111 MBq (3 mCi) or 370 MBq (10 mCi) of florbetapir F 18 in patients with Alzheimer's disease (AD) (n = 9) and younger healthy controls (YHCs) (n = 11). In a separate set of subjects (AD, n = 10; YHCs, n = 10), test-retest reliability was evaluated by comparing intrasubject visual read ratings and SUVrs for 2 PET images acquired within 4 wk of each other.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2012, Vol 53, Issue 3, p378
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.111.090340