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- Title
Developmental changes in P-glycoprotein function in the blood-brain barrier of nonhuman primates: PET study with R-11C-verapamil and 11C-oseltamivir.
- Authors
Takashima, Tadayuki; Yokoyama, Chihiro; Mizuma, Hiroshi; Yamanaka, Hajime; Wada, Yasuhiro; Onoe, Kayo; Nagata, Hiroko; Tazawa, Shusaku; Doi, Hisashi; Takahashi, Kazuhiro; Morita, Masataka; Kanai, Motomu; Shibasaki, Masakatsu; Kusuhara, Hiroyuki; Sugiyama, Yuichi; Onoe, Hirotaka; Watanabe, Yasuyoshi
- Abstract
P-glycoprotein (P-gp) plays a pivotal role in limiting the penetration of xenobiotic compounds into the brain at the blood-brain barrier (BBB), where its expression increases with maturation in rats. We investigated developmental changes in P-gp function in the BBB of nonhuman primates using PET with R-(11)C-verapamil, a PET radiotracer useful for evaluating P-gp function. In addition, developmental changes in the brain penetration of (11)C-oseltamivir, a substrate for P-gp, was investigated as practical examples.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, Vol 52, Issue 6, p950
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.110.083949