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- Title
Dual-biomarker imaging of regional cerebral amyloid load and neuronal activity in dementia with PET and 11C-labeled Pittsburgh compound B.
- Authors
Meyer, Philipp T; Hellwig, Sabine; Amtage, Florian; Rottenburger, Christof; Sahm, Ursula; Reuland, Peter; Weber, Wolfgang A; Hüll, Michael
- Abstract
PET studies with biomarkers of regional neuronal activity (cerebral glucose metabolism or blood flow [CBF]) and amyloid-β (Aβ) depositions provide complementary information for the early diagnosis of dementia and follow-up of patients with dementia. We investigated the validity of relative regional CBF estimates (R(1)) gained from pharmacokinetic analyses of (11)C-labeled Pittsburgh compound B ((11)C-PIB) PET studies as a marker of neuronal activity and neurodegeneration.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, Vol 52, Issue 3, p393
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.110.083683