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- Title
Accuracy and reproducibility of absolute quantification of myocardial focal tracer uptake from molecularly targeted SPECT/CT: a canine validation.
- Authors
Liu, Yi-Hwa; Sahul, Zakir; Weyman, Christopher A; Dione, Donald P; Dobrucki, Wawrzyniec L; Mekkaoui, Choukri; Brennan, Matthew P; Ryder, William J; Sinusas, Albert J
- Abstract
Accurate and reproducible SPECT quantification of myocardial molecular processes remains a challenge because of the complication of heterogeneous background and extracardiac activity adjacent to the heart, which causes errors in the estimation of myocardial focal tracer uptake. Our aim in this study was to introduce a heuristic method for the correction of extracardiac activity into SPECT quantification and validate the modified quantification method for accuracy and reproducibility using a canine model.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, Vol 52, Issue 3, p453
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.110.082214