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- Title
Monodispersed DOTA-PEG-conjugated anti-TAG-72 diabody has low kidney uptake and high tumor-to-blood ratios resulting in improved 64Cu PET.
- Authors
Li, Lin; Turatti, Fabio; Crow, Desiree; Bading, James R; Anderson, Anne-Line; Poku, Erasmus; Yazaki, Paul J; Williams, Lawrence E; Tamvakis, Debra; Sanders, Paul; Leong, David; Raubitschek, Andrew; Hudson, Peter J; Colcher, David; Shively, John E
- Abstract
Diabodies are noncovalent dimers of single-chain antibody fragments that retain the avidity of intact IgG but have more favorable blood clearance than intact IgG. Radiometals offer a wide range of half-lives and emissions for matching imaging and therapy requirements and provide facile labeling of chelate-antibody conjugates. However, because of their high retention and metabolism in the kidney, the use of radiometal-labeled diabodies can be problematic for both imaging and therapy.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2010, Vol 51, Issue 7, p1139
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.109.074153