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- Title
Small-animal PET/CT for monitoring the development and response to chemotherapy of thymic lymphoma in Trp53-/- mice.
- Authors
Walter, Martin A; Hildebrandt, Isabel J; Hacke, Katrin; Kesner, Adam L; Kelly, Owen; Lawson, Gregory W; Phelps, Michael E; Czernin, Johannes; Weber, Wolfgang A; Schiestl, Robert H
- Abstract
Transgenic mouse models of human cancers represent one of the most promising approaches to elucidate clinically relevant mechanisms of action and provide insights into the treatment efficacy of new antitumor drugs. The use of Trp53 transgenic mice (Trp53 knockout [Trp53(-/-)] mice) for these kinds of studies is, so far, restricted by limitations in detecting developing tumors and the lack of noninvasive tools for monitoring tumor growth, progression, and treatment response.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2010, Vol 51, Issue 8, p1285
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.109.073585