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- Title
PET of hypoxia with 89Zr-labeled cG250-F(ab')2 in head and neck tumors.
- Authors
Hoeben, Bianca A W; Kaanders, Johannes H A M; Franssen, Gerben M; Troost, Esther G C; Rijken, Paul F J W; Oosterwijk, Egbert; van Dongen, Guus A M S; Oyen, Wim J G; Boerman, Otto C; Bussink, Johan
- Abstract
Hypoxic tumor cells are resistant to radiotherapy and various chemotherapeutic agents. The pretherapeutic assessment of intratumoral hypoxia may allow selection of patients for intensified treatment regimens. Carbonic anhydrase IX (CAIX) is an endogenous hypoxia-related protein involved in pH regulation and is upregulated in many tumor types. Radionuclide imaging using a monoclonal antibody against CAIX, such as cG250, may allow noninvasive PET of hypoxia in these tumor types. The aims of this study were to investigate whether (89)Zr-labeled cG250-F(ab')(2) allowed visualization of tumor hypoxia using small-animal PET and whether the tracer showed spatial correlation to the microscopic distribution of CAIX-expressing cells in a human head and neck xenograft tumor model.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2010, Vol 51, Issue 7, p1076
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.109.073189