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- Title
Development of a universal anti-polyethylene glycol reporter gene for noninvasive imaging of PEGylated probes.
- Authors
Chuang, Kuo-Hsiang; Wang, Hsin-Ell; Cheng, Ta-Chun; Tzou, Shey-Cherng; Tseng, Wei-Lung; Hung, Wen-Chun; Tai, Ming-Hong; Chang, Tien-Kuei; Roffler, Steve R; Cheng, Tian-Lu
- Abstract
A reporter gene can provide important information regarding the specificity and efficacy of gene or cell therapies. Although reporter genes are increasingly used in experimental and clinical studies, a highly specific yet nonimmunogenic reporter that can track genes and cells in vivo by multiple imaging technologies still awaits development. In this study, we constructed a versatile and nonimmunogenic reporter gene to noninvasively image gene expression or cell delivery by optical imaging, MRI, and small-animal PET.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2010, Vol 51, Issue 6, p933
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.109.071977