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- Title
123I-5-IA-85380 SPECT imaging of nicotinic receptors in Alzheimer disease and mild cognitive impairment.
- Authors
Mitsis, Effie M; Reech, Kristina M; Bois, Frederic; Tamagnan, Gilles D; Macavoy, Martha G; Seibyl, John P; Staley, Julie K; van Dyck, Christopher H
- Abstract
Postmortem binding studies have established that the concentration of alpha(4)beta(2)-nicotinic acetylcholine receptors (alpha(4)beta(2)-nAChR) is reduced in advanced Alzheimer disease (AD). However, the status of this receptor in mild or prodromal AD has remained the subject of controversy.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2009, Vol 50, Issue 9, p1455
- ISSN
0161-5505
- Publication type
Journal Article
- DOI
10.2967/jnumed.109.064030