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- Title
Serial noninvasive targeted imaging of peripheral angiogenesis: validation and application of a semiautomated quantitative approach.
- Authors
Dobrucki, Lawrence W; Dione, Donald P; Kalinowski, Leszek; Dione, Donna; Mendizabal, Marivi; Yu, Jun; Papademetris, Xenophon; Sessa, William C; Sinusas, Albert J
- Abstract
Previous studies by our group have demonstrated the feasibility of noninvasive imaging of alpha(v) integrin to assess temporal and spatial changes in peripheral and myocardial angiogenesis. In this study, we validate the reproducibility, accuracy, and applicability of a new semiautomated noninvasive approach for serial quantitative evaluation of targeted micro-SPECT/CT images of peripheral angiogenesis in wild-type and endothelial nitric oxide sythase (eNOS)-deficient (eNOS-/-) mice subjected to hindlimb ischemia.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2009, Vol 50, Issue 8, p1356
- ISSN
0161-5505
- Publication type
Journal Article
- DOI
10.2967/jnumed.108.060822