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- Title
Quantification of cerebral glucose metabolic rate in mice using 18F-FDG and small-animal PET.
- Authors
Yu, Amy S; Lin, Hong-Dun; Huang, Sung-Cheng; Phelps, Michael E; Wu, Hsiao-Ming
- Abstract
The aim of this study was to evaluate various methods for estimating the metabolic rate of glucose utilization in the mouse brain (cMR(glc)) using small-animal PET and reliable blood curves derived by a microfluidic blood sampler. Typical values of (18)F-FDG rate constants of normal mouse cerebral cortex were estimated and used for cMR(glc) calculations. The feasibility of using the image-derived liver time-activity curve as a surrogate input function in various quantification methods was also evaluated.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2009, Vol 50, Issue 6, p966
- ISSN
0161-5505
- Publication type
Journal Article
- DOI
10.2967/jnumed.108.060533