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- Title
11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls.
- Authors
Goland, Robin; Freeby, Matthew; Parsey, Ramin; Saisho, Yoshifumi; Kumar, Dileep; Simpson, Norman; Hirsch, Joy; Prince, Martin; Maffei, Antonella; Mann, J John; Butler, Peter C; Van Heertum, Ronald; Leibel, Rudolph L; Ichise, Masanori; Harris, Paul E
- Abstract
Type 2 vesicular monoamine transporter (VMAT2), found in the brain, is also expressed by beta-cells of the pancreas in association with insulin. Preclinical experiments suggested that (11)C-dihydrotetrabenazine PET-measured VMAT2 binding might serve as a biomarker of beta-cell mass. We evaluated the feasibility of (11)C-dihydrotetrabenazine PET quantification of pancreatic VMAT2 binding in healthy subjects and patients with long-standing type 1 diabetes.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2009, Vol 50, Issue 3, p382
- ISSN
0161-5505
- Publication type
Journal Article
- DOI
10.2967/jnumed.108.054866