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- Title
Brain adenosine A2A receptor occupancy by a novel A1/A2A receptor antagonist, ASP5854, in rhesus monkeys: relationship to anticataleptic effect.
- Authors
Mihara, Takuma; Noda, Akihiro; Arai, Hiroshi; Mihara, Kayoko; Iwashita, Akinori; Murakami, Yoshihiro; Matsuya, Takahiro; Miyoshi, Sosuke; Nishimura, Shintaro; Matsuoka, Nobuya
- Abstract
The purpose of the present study was to measure adenosine A(2A) receptor (A(2A)R) occupancy in the brain by a novel adenosine A(1)/A(2A) antagonist, 5-[5-amino-3-(4fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1H)-one (ASP5854), and to determine the degree of receptor occupancy necessary to inhibit haloperidol-induced catalepsy in rhesus monkeys.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2008, Vol 49, Issue 7, p1183
- ISSN
0161-5505
- Publication type
Journal Article
- DOI
10.2967/jnumed.108.051474