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- Title
Small-animal PET imaging of human epidermal growth factor receptor type 2 expression with site-specific 18F-labeled protein scaffold molecules.
- Authors
Cheng, Zhen; De Jesus, Omayra Padilla; Namavari, Mohammad; De, Abhijit; Levi, Jelena; Webster, Jack Matt; Zhang, Rong; Lee, Brian; Syud, Faisal A; Gambhir, Sanjiv Sam
- Abstract
Human epidermal growth factor receptor type 2 (HER2) is a well-established tumor biomarker that is overexpressed in a wide variety of cancers and that serves as a molecular target for therapeutic intervention. HER2 also serves as a prognostic indicator of patient survival and as a predictive marker of the response to antineoplastic therapy. The development of (18)F-labeled biomolecules for PET imaging of HER2 (HER2 PET) is very important because it may provide a powerful tool for the early detection of HER2-positive tumor recurrence and for the monitoring of HER2-based tumor treatment.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2008, Vol 49, Issue 5, p804
- ISSN
0161-5505
- Publication type
Journal Article
- DOI
10.2967/jnumed.107.047381