We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Dynamic small-animal PET imaging of tumor proliferation with 3'-deoxy-3'-18F-fluorothymidine in a genetically engineered mouse model of high-grade gliomas.
- Authors
Bradbury, Michelle S; Hambardzumyan, Dolores; Zanzonico, Pat B; Schwartz, Jazmin; Cai, Shangde; Burnazi, Eva M; Longo, Valerie; Larson, Steven M; Holland, Eric C
- Abstract
3'-Deoxy-3'-(18)F-fluorothymidine ((18)F-FLT), a partially metabolized thymidine analog, has been used in preclinical and clinical settings for the diagnostic evaluation and therapeutic monitoring of tumor proliferation status. We investigated the use of (18)F-FLT for detecting and characterizing genetically engineered mouse (GEM) high-grade gliomas and evaluating the pharmacokinetics in GEM gliomas and normal brain tissue. Our goal was to develop a robust and reproducible method of kinetic analysis for the quantitative evaluation of tumor proliferation.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2008, Vol 49, Issue 3, p422
- ISSN
0161-5505
- Publication type
Journal Article
- DOI
10.2967/jnumed.107.047092