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- Title
11C-AC-5216: a novel PET ligand for peripheral benzodiazepine receptors in the primate brain.
- Authors
Zhang, Ming-Rong; Kumata, Katsushi; Maeda, Jun; Yanamoto, Kazuhiko; Hatori, Akiko; Okada, Maki; Higuchi, Makoto; Obayashi, Shigeru; Suhara, Tetsuya; Suzuki, Kazutoshi
- Abstract
Developing a PET ligand for imaging of the peripheral benzodiazepine receptor (PBR; Translocator Protein [18 kDa] TSPO) is of great importance for studying its role in glial cells in the injured brain and in neurodegenerative disorders, such as Alzheimer's disease. The aim of this study was to synthesize and evaluate N-benzyl-N-ethyl-2-(7-(11)C-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide ((11)C-AC-5216) as a PET ligand for imaging PBR in the primate brain.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2007, Vol 48, Issue 11, p1853
- ISSN
0161-5505
- Publication type
Journal Article
- DOI
10.2967/jnumed.107.043505