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- Title
Temporal change in human nicotinic acetylcholine receptor after smoking cessation: 5IA SPECT study.
- Authors
Mamede, Marcelo; Ishizu, Koichi; Ueda, Masashi; Mukai, Takahiro; Iida, Yasuhiko; Kawashima, Hidekazu; Fukuyama, Hidenao; Togashi, Kaori; Saji, Hideo
- Abstract
Nicotinic acetylcholine receptors (nAChRs) are of great interest because they are implicated in various brain functions. They also are thought to play an important role in nicotine addiction of smokers. Chronic (-)-nicotine, a nAChR agonist, treatment in mice and rats elicits a dose-dependent increase in nAChRs in the brain. Upregulation of nAChRs in postmortem human brains of smokers has also been reported. However, changes in nAChRs after cigarette smoking cessation in humans are poorly understood. The aim of this study was to detect the dynamic changes of nAChRs after smoking and smoking cessation in the brains of living subjects.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2007, Vol 48, Issue 11, p1829
- ISSN
0161-5505
- Publication type
Journal Article
- DOI
10.2967/jnumed.107.043471