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- Title
microPET of tumor integrin alphavbeta3 expression using 18F-labeled PEGylated tetrameric RGD peptide (18F-FPRGD4).
- Authors
Wu, Zhanhong; Li, Zi-Bo; Chen, Kai; Cai, Weibo; He, Lina; Chin, Frederick T; Li, Fang; Chen, Xiaoyuan
- Abstract
In vivo imaging of alpha(v)beta(3) expression has important diagnostic and therapeutic applications. Multimeric cyclic RGD peptides are capable of improving the integrin alpha(v)beta(3)-binding affinity due to the polyvalency effect. Here we report an example of (18)F-labeled tetrameric RGD peptide for PET of alpha(v)beta(3) expression in both xenograft and spontaneous tumor models.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2007, Vol 48, Issue 9, p1536
- ISSN
0161-5505
- Publication type
Journal Article
- DOI
10.2967/jnumed.107.040816