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- Title
Human antibody against C domain of tenascin-C visualizes murine atherosclerotic plaques ex vivo.
- Authors
von Lukowicz, Tobias; Silacci, Michela; Wyss, Matthias T; Trachsel, Eveline; Lohmann, Christine; Buck, Alfred; Lüscher, Thomas F; Neri, Dario; Matter, Christian M
- Abstract
Targeting proteins that are overexpressed in atherosclerotic plaques may open novel diagnostic applications. The C domain of tenascin-C is absent from normal adult tissues but can be inserted during tumor progression or tissue repair into the molecule by alternative splicing. We tested the ability of the human antibody G11, specific to this antigen, to reveal murine atherosclerotic plaques ex vivo. The antibody directed against the extra domain B of fibronectin (L19) was used as a reference.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2007, Vol 48, Issue 4, p582
- ISSN
0161-5505
- Publication type
Journal Article
- DOI
10.2967/jnumed.106.036046