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- Title
Cross-reactive antibody to swine influenza A(H3N2) subtype virus in children and adults before and after immunisation with 2010/11 trivalent inactivated influenza vaccine in Canada, August to November 2010.
- Authors
Skowronski, D M; De Serres, G; Janjua, N Z; Gardy, J L; Gilca, V; Dionne, M; Hamelin, M E; Rhéaume, C; Boivin, G
- Abstract
In pre- and post-immunisation sera from children (17-120 months-old) and adults (20-59 years-old) immunised with 2010/11 trivalent inactivated influenza vaccine, we assessed age-related patterns of sero-susceptibility and vaccine-induced cross-reactive antibodies to a representative swine H3N2 (swH3N2) and a related ancestral human H3N2 (A/Sydney/5/1997) influenza virus. Few children but a greater proportion of adults showed pre-immunisation haemagglutination inhibition titres ≥40 to either virus. Titres increased with age among children but decreased in adults. Fewer than 20% showed a four-fold rise in antibody titres to either virus following immunisation. Further investigation is warranted to guide ongoing risk assessment and response to emerging swine H3N2 viruses.
- Publication
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2012, Vol 17, Issue 4
- ISSN
1560-7917
- Publication type
Journal Article
- DOI
10.2807/ese.17.04.20066-en