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Title
Orally administered doxycycline accumulates in synovial fluid compared to plasma.
Authors
Schnabel, L V; Papich, M G; Watts, A E; Fortier, L A
Abstract
Tetracycline compounds have been used to slow the progression of osteoarthritis (OA) and rheumatoid arthritis but the concentration of doxycycline attained in synovial fluid following oral, low-dose administration has yet to be determined.