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- Title
Effect of intravenous lidocaine administration on laminar inflammation in the black walnut extract model of laminitis.
- Authors
Williams, J M; Lin, Y J; Loftus, J P; Faleiros, R R; Peroni, J F; Hubbell, J A E; Ravis, W R; Belknap, J K
- Abstract
Laminitis is a serious complication of horses suffering from sepsis/endotoxaemia-related events. Laminitis in horses and organ injury in human sepsis are both reported to involve inflammatory injury to the laminae/organs including early activation of endothelium and leucocytes leading to emigration of neutrophils into the tissue interstitium. In the black walnut extract (BWE) model, systemic inflammatory events coincide with marked increase in laminar mRNA concentrations of inflammatory genes including proinflammatory cytokines (i.e. IL-1beta, IL-6), COX-2, chemokines (i.e. IL-8) and endothelial adhesion molecules (i.e. ICAM-1 and E-selectin). In models of human sepsis, i.v. lidocaine has been reported to decrease leucocyte and endothelial activation, and the expression of proinflammatory cytokines and chemokines.
- Publication
Equine veterinary journal, 2010, Vol 42, Issue 3, p261
- ISSN
0425-1644
- Publication type
Journal Article
- DOI
10.2746/042516409X475760