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- Title
Treatment-recalcitrant chronic rhinosinusitis with polyps is associated with altered epithelial cell expression of interleukin-33.
- Authors
Reh, Douglas D; Wang, Yadong; Ramanathan, Murugappan, Jr; Lane, Andrew P
- Abstract
Abnormalities in host mucosal immunity exist in chronic rhinosinusitis with nasal polyps (CRSwNPs), but it is unclear whether this is a cause or an effect of the eosinophilic inflammation and frequent microbial colonization that characterizes the disease. Sinonasal epithelial cells (SNECs) are critical participants in healthy antimicrobial innate immune defense. They also can promote Th2 inflammation with various mediators, including interleukin (IL)-33, which induces T helper cells to produce Th2 cytokines.
- Publication
American journal of rhinology & allergy, 2010, Vol 24, Issue 2, p105
- ISSN
1945-8932
- Publication type
Journal Article
- DOI
10.2500/ajra.2010.24.3446