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- Title
Zinc increases ciliary beat frequency in a calcium-dependent manner.
- Authors
Woodworth, Bradford A; Zhang, Shaoyan; Tamashiro, Edwin; Bhargave, Geeta; Palmer, James N; Cohen, Noam A
- Abstract
Dynamic regulation of respiratory ciliary beat frequency (CBF) is regulated by fluxes in intracellular calcium (Ca(2+)). P2X receptors (P2XR) are extracellular ATP-gated, Ca(2+)-permeable, nonselective cation channels. Zinc increases intracellular Ca(2+) in a sodium (Na(+))-free environment through activation of P2XR channels. We hypothesize that topical zinc increases CBF in a Ca(2+)-dependent fashion as a result of this mechanism.
- Publication
American journal of rhinology & allergy, 2010, Vol 24, Issue 1, p6
- ISSN
1945-8932
- Publication type
Journal Article
- DOI
10.2500/ajra.2010.24.3379