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- Title
An in vitro model of Pseudomonas aeruginosa biofilms on viable airway epithelial cell monolayers.
- Authors
Woodworth, Bradford A; Tamashiro, Edwin; Bhargave, Geeta; Cohen, Noam A; Palmer, James N
- Abstract
Chronic rhinosinusitis (CRS) that is refractory to medical or surgical intervention may involve a particularly resistant form of infection known as a bacterial biofilm. Bacterial biofilms are three-dimensional aggregates of bacteria that often are recalcitrant to antibiotics secondary to physical barrier characteristics. To date, all studies investigating biofilms in CRS have been descriptive in either human or animal tissue. To better understand the interactions of bacterial biofilms with respiratory epithelium, we describe an in vitro model of biofilm sinusitis by establishing mature biofilms on airway epithelial air-liquid interface cultures.
- Publication
American journal of rhinology, 2008, Vol 22, Issue 3, p235
- ISSN
1050-6586
- Publication type
Journal Article
- DOI
10.2500/ajr.2008.22.3178