We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Inflammation-sensitive plasma proteins are associated with future weight gain.
- Authors
Engströ, Gunnar; Engström, Gunnar; Hedblad, Bo; Stavenow, Lars; Lind, Peter; Janzon, Lars; Lindgärde, Folke; Engström, Gunnar; Lindgärde, Folke
- Abstract
Cross-sectional studies have associated obesity and other components of the so-called metabolic syndrome with low-grade inflammation. The temporal and causal relations of this association have not been fully explored. This study explored whether elevated levels of inflammation-sensitive plasma proteins (ISPs) (fibrinogen, orosomucoid, alpha1-antitrypsin, haptoglobin, and ceruloplasmin) are associated with future weight gain. Five ISPs were measured in 2,821 nondiabetic healthy men (38-50 years of age) who were reexamined after a mean follow-up of 6.1 years. Future weight gain was studied in relation to the number of elevated ISPs (i.e., in the top quartile). The proportion with a large weight gain (75th percentile >/= 3.8 kg) was 21.0, 25.9, 26.8, and 28.3%, respectively, among men with none, one, two, and three or more ISPs in the top quartile (P for trend 0.0005). This relation remained significant after adjustments for weight at baseline, follow-up time, height (at baseline and follow-up), physical inactivity (at baseline and follow-up), smoking (at baseline and follow-up), high alcohol consumption, and insulin resistance. The relations were largely similar for all individual ISPs. Elevated ISP levels predict a large weight gain in middle-aged men. This relation could contribute to the relation between inflammation, the metabolic syndrome, and cardiovascular disease.
- Publication
Diabetes, 2003, Vol 52, Issue 8, p2097
- ISSN
0012-1797
- Publication type
Academic Journal
- DOI
10.2337/diabetes.52.8.2097