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- Title
Intracellular targeting of protein kinases and phosphatases.
- Authors
Alto, Neal; Carlisle Michel, Jennifer J; Dodge, Kimberly L; Langeberg, Lorene K; Scott, John D
- Abstract
Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger-mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). This study focused on recent advances that further our understanding of AKAPs, with particular emphasis on the bidirectional regulation of signaling events by AKAP signaling complexes and their contribution to the control of actin reorganization events.
- Publication
Diabetes, 2002, Vol 51 Suppl 3, pS385
- ISSN
0012-1797
- Publication type
Journal Article
- DOI
10.2337/diabetes.51.2007.s385