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Title
Insulin-Induced Insulin Receptor Substrate-1 Degradation is mediated by the Proteasome Degradation Pathway.
Authors
Xiao Jian Sun; Goldberg, Jonathan L.; Li-ya Qiao; Mitchell, John J.
Abstract
Demonstrates that insulin-induced degradation of insulin receptor substrate (IRS)-1 protein is mediated by proteasome degradation pathway. Prevention of insulin-induced degradation of IRS-1 by pretreatment with lactacystin, a proteasome degradation inhibitor.