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- Title
Autoimmune destruction of islets transplanted into RT6-depleted diabetes-resistant BB/Wor rats.
- Authors
Gottlieb, P A; Berrios, J P; Mariani, G; Handler, E S; Greiner, D; Mordes, J P; Rossini, A A
- Abstract
We report a novel animal model of islet transplantation that distinguishes recurrence of autoimmunity from allograft rejection. In this study, diabetes-resistant (DR) BB rats, less than 1% of which develop spontaneous diabetes, were made hyperglycemic by either a single injection of streptozocin (STZ) or in vivo immune elimination of a regulatory T-lymphocyte subset that expresses the RT6 alloantigen. DR islet grafts were then transplanted into both groups. DR transplants into STZ-induced diabetic DR rats produced long-term normoglycemia. In contrast, DR transplants into DR rats that had been treated with anti-RT6 monoclonal antibody were all destroyed within an average of 4 days. Allogeneic islets transplanted into both STZ-induced and RT6-depleted diabetic DR rats were rejected within a mean of 3 days. We conclude that failure of DR islet grafts in RT6-depleted diabetic DR BB rats represents recurrent autoimmunity.
- Publication
Diabetes, 1990, Vol 39, Issue 5, p643
- ISSN
0012-1797
- Publication type
Journal Article
- DOI
10.2337/diab.39.5.643