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- Title
Regional brain glucose metabolism and blood flow in streptozocin-induced diabetic rats.
- Authors
Jakobsen, J; Nedergaard, M; Aarslew-Jensen, M; Diemer, N H
- Abstract
Brain regional glucose metabolism and regional blood flow were measured from autoradiographs by the uptake of [3H]-2-deoxy-D-glucose and [14C]iodoantipyrine in streptozocin-induced diabetic (STZ-D) rats. After 2 days of diabetes, glucose metabolism in the neocortex, basal ganglia, and white matter increased by 34, 37, and 8%, respectively, whereas blood flow was unchanged. After 4 mo, glucose metabolism in the same three regions was decreased by 32, 43, and 60%. This reduction was paralleled by a statistically nonsignificant reduction in blood flow in neocortex and basal ganglia. It is suggested that the decrease of brain glucose metabolism in STZ-D reflects increased ketone body oxidation and reduction of electrochemical work.
- Publication
Diabetes, 1990, Vol 39, Issue 4, p437
- ISSN
0012-1797
- Publication type
Journal Article
- DOI
10.2337/diab.39.4.437