We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Spontaneous diabetes mellitus in the BB/W rat. Effects of glucocorticoids, cyclosporin-A, and antiserum to rat lymphocytes.
- Authors
Like, A A; Anthony, M; Guberski, D L; Rossini, A A
- Abstract
Combination immunosuppression therapy with long-acting glucocorticoids, cyclosporin-A, and antiserum to rat lymphocytes (ALS) reduced the severity of spontaneous diabetes among BioBreeding/Worcester rats and decreased the frequency of diabetes in susceptible littermates. Combination therapy with glucocorticoids and three injections of ALS reversed hyperglycemia in a significant number of acutely diabetic animals. These results strengthen the hypothesis that autoimmunity plays a role in the pathogenesis of diabetes in these animals and increase our understanding of the requirements of treatment protocols for the prevention and cure of this spontaneous syndrome.
- Publication
Diabetes, 1983, Vol 32, Issue 4, p326
- ISSN
0012-1797
- Publication type
Journal Article
- DOI
10.2337/diab.32.4.326