We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Co-occurrence of risk alleles in or near genes modulating insulin secretion predisposes obese youth to prediabetes.
- Authors
Giannini, Cosimo; Dalla Man, Chiara; Groop, Leif; Cobelli, Claudio; Zhao, Hongyu; Shaw, Melissa M; Duran, Elvira; Pierpont, Bridget; Bale, Allen E; Caprio, Sonia; Santoro, Nicola
- Abstract
Paralleling the rise of pediatric obesity, the prevalence of impaired glucose tolerance (IGT) and type 2 diabetes (T2D) is increasing among youth. In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating insulin secretion (TCF7L2 rs7903146, IGF2BP2 rs4402960, CDKAL1 rs7754840, HHEX rs1111875, and HNF1A rs1169288) is associated with a higher risk of IGT/T2D in obese children and adolescents.
- Publication
Diabetes care, 2014, Vol 37, Issue 2, p475
- ISSN
1935-5548
- Publication type
Journal Article
- DOI
10.2337/dc13-1458