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- Title
The association between hepatic fat content and liver injury in obese children and adolescents: effects of ethnicity, insulin resistance, and common gene variants.
- Authors
Santoro, Nicola; Feldstein, Ariel E; Enoksson, Erik; Pierpont, Bridget; Kursawe, Romy; Kim, Grace; Caprio, Sonia
- Abstract
Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NASH) are highly prevalent in obese youth. Herein, we aimed to study the association between hepatic fat accumulation as assessed by magnetic resonance imaging and circulating levels of cytokeratin-18 (CK-18) fragments, a robust NASH biomarker, and to explore the impact on this association of ethnicity, insulin resistance, and single nucleotide polymorphisms (SNPs) associated with steatosis (rs738409 in the PNPLA3, rs1260326 in the GCKR) or NASH severity (rs2645424 in the FDFT1).
- Publication
Diabetes care, 2013, Vol 36, Issue 5, p1353
- ISSN
1935-5548
- Publication type
Journal Article
- DOI
10.2337/dc12-1791