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Title
Central role of fatty liver in the pathogenesis of insulin resistance in obese adolescents.
Authors
D'Adamo, Ebe; Cali, Anna M G; Weiss, Ram; Santoro, Nicola; Pierpont, Bridget; Northrup, Veronika; Caprio, Sonia
Abstract
We evaluated the role of fatty liver in the alteration of insulin sensitivity and beta-cell function in two groups of obese adolescents, differing in hepatic fat content (hepatic fat fraction [HFF]) but with similar intrabdominal intramyocellular lipid content (IMCL) and overall degree of obesity.