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- Title
The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy.
- Authors
Rosenstock, Julio; Banarer, Salomon; Fonseca, Vivian A; Inzucchi, Silvio E; Sun, William; Yao, Wenqing; Hollis, Gregory; Flores, Robert; Levy, Richard; Williams, William V; Seckl, Jonathan R; Huber, Reid; INCB13739-202 Principal Investigators
- Abstract
11-Beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) converts inactive cortisone into active cortisol, thereby amplifying intracellular glucocorticoid action. The efficacy and safety of the 11betaHSD1 inhibitor INCB13739 were assessed when added to ongoing metformin monotherapy in patients with type 2 diabetes exhibiting inadequate glycemic control (A1C 7-11%).
- Publication
Diabetes care, 2010, Vol 33, Issue 7, p1516
- ISSN
1935-5548
- Publication type
Journal Article
- DOI
10.2337/dc09-2315