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- Title
Independent metabolic syndrome variants predict new-onset coronary artery disease.
- Authors
Vaidya, Dhananjay; Mathias, Rasika A; Kral, Brian G; Yanek, Lisa R; Becker, Lewis C; Becker, Diane M
- Abstract
Any combination of metabolic abnormalities may constitute the metabolic syndrome (MetS), conferring coronary artery disease (CAD) risk, but the independent effect of different combinations on CAD onset remains unknown. RESEARCH DESIGN AND METHODS" Healthy adult siblings (n = 987) of premature CAD (<60 years) case subjects were followed for 9.8 +/- 3.8 years. Baseline MetS variables (insulin sensitivity index, waist circumference, systolic blood pressure, HDL cholesterol, and triglycerides) were recombined into five principal components (PC1-5), and risk factor-adjusted proportional hazards for CAD onset of median-dichotomized PCs were estimated.
- Publication
Diabetes care, 2010, Vol 33, Issue 6, p1376
- ISSN
1935-5548
- Publication type
Journal Article
- DOI
10.2337/dc09-2211