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- Title
Fully automated closed-loop insulin delivery versus semiautomated hybrid control in pediatric patients with type 1 diabetes using an artificial pancreas.
- Authors
Weinzimer, Stuart A; Steil, Garry M; Swan, Karena L; Dziura, Jim; Kurtz, Natalie; Tamborlane, William V
- Abstract
The most promising beta-cell replacement therapy for children with type 1 diabetes is a closed-loop artificial pancreas incorporating continuous glucose sensors and insulin pumps. The Medtronic MiniMed external physiological insulin delivery (ePID) system combines an external pump and sensor with a variable insulin infusion rate algorithm designed to emulate the physiological characteristics of the beta-cell. However, delays in insulin absorption associated with the subcutaneous route of delivery inevitably lead to large postprandial glucose excursions.
- Publication
Diabetes care, 2008, Vol 31, Issue 5, p934
- ISSN
1935-5548
- Publication type
Journal Article
- DOI
10.2337/dc07-1967