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- Title
Rarefaction of the peripheral nerve network in diabetic patients is associated with a pronounced reduction of terminal Schwann cells.
- Authors
Reinisch, Christina M; Traxler, Hannes; Piringer, Stefanie; Tangl, Stefan; Nader, Alexander; Tschachler, Erwin
- Abstract
Peripheral neuropathy is the most frequent neurological complication in diabetic patients. The diagnosis is established by both clinical neurological examination and demonstration of reduced epidermal nerve fibers in skin biopsies (1). Whereas the decrease of free nerve endings has been extensively studied in diabetic patients (2,3), no data are available on possible changes of terminal Schwann cells. Besides their role as scaffold for peripheral nerves, they also play an important role in supporting survival and function of peripheral nerves (4).
- Publication
Diabetes care, 2008, Vol 31, Issue 6, p1219
- ISSN
1935-5548
- Publication type
Journal Article
- DOI
10.2337/dc07-1832