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- Title
Increased body iron stores of obese women with polycystic ovary syndrome are a consequence of insulin resistance and hyperinsulinism and are not a result of reduced menstrual losses.
- Authors
Luque-Ramírez, Manuel; Alvarez-Blasco, Francisco; Botella-Carretero, José I; Sanchón, Raul; San Millán, José L; Escobar-Morreale, Héctor F
- Abstract
Increased serum ferritin levels, indicating increased body iron stores, have been found in overweight and obese women with polycystic ovary syndrome (PCOS). This finding might result from reduced menstrual losses secondary to oligo- or amenorrhea or from hyperinsulinism secondary to insulin resistance, because insulin favors the intestinal absorption and the tissue deposition of iron. To explore which of these mechanisms is responsible for the increase in body iron stores in women with PCOS, we have monitored the changes in serum ferritin levels during treatment with an antiandrogenic oral contraceptive or an insulin sensitizer.
- Publication
Diabetes care, 2007, Vol 30, Issue 9, p2309
- ISSN
1935-5548
- Publication type
Journal Article
- DOI
10.2337/dc07-0642