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- Title
Visceral Fatness and Insulin Sensitivity in Women With a Previous History of Gestational Diabetes Mellitus.
- Authors
Soo Lim; Sung Hee Choi; Young Joo Park; Kyong Soo Park; Hong Kyu Lee; Jang, Hak C.; Cho, Nam H.; Metzger, Boyd E.
- Abstract
OBJECTIVE -- The purpose of this study was to investigate the insulin sensitivity and visceral fatness in women with previous gestational diabetes mellitus (GDM), who are prone to develop type 2 diabetes. RESEARCH DESIGN AND METHODS -- A 75-g oral glucose tolerance test (OGTT) performed 1 year postpartum identified 21 GAD- women with previous GDM and impaired glucose tolerance (GDM-IGT). Sixty age- and BMI-matched women with normal glucose tolerance (GDM-NGT) were selected by 1:3 matching to the GDM-IGT group. Another 18 women with normal glucose metabolism during a previous pregnancy and no family history of diabetes were recruited as the normal control group. Age and BMI matching was performed using a range of ± 1.0 years and ± 1.0 kg/m², respectively. Total body fat was measured by tetrapolar bioelectrical impedance, and visceral fat was determined using a single cut of a computed tomography scan. Insulin sensitivity was determined by the minimal model technique using the frequently sampled intravenous glucose tolerance test. RESULTS -- One year postpartum, visceral fat was greater in the GDM-IGT group than in the age- and BMI-matched GDM-NGT or normal control groups. The insulin sensitivity index was lower in the GDM-IGT group than in the GDM-NGT or normal control groups. β-Cell function, as measured by the acute insulin response to glucose, was also lower in GDM-IGT. CONCLUSIONS -- High body fat content, especially visceral fat content, and a low insulin response to glucose seem to contribute simultaneously to the development of impaired glucose metabolism in Korean women with previous GDM.
- Publication
Diabetes Care, 2007, Vol 30, Issue 2, p348
- ISSN
0149-5992
- Publication type
Academic Journal
- DOI
10.2337/dc06-1405