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Title
Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice.
Authors
Thorel, Fabrizio; Damond, Nicolas; Chera, Simona; Wiederkehr, Andreas; Thorens, Bernard; Meda, Paolo; Wollheim, Claes B; Herrera, Pedro L
Abstract
To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic α-cells and how this sudden massive depletion affects β-cell function and blood glucose homeostasis.