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- Title
Aberrant accumulation of undifferentiated myeloid cells in the adipose tissue of CCR2-deficient mice delays improvements in insulin sensitivity.
- Authors
Gutierrez, Dario A; Kennedy, Arion; Orr, Jeb S; Anderson, Emily K; Webb, Corey D; Gerrald, William K; Hasty, Alyssa H
- Abstract
Mice with CCR2 deficiency are protected from insulin resistance but only after long periods of high-fat diet (HFD) feeding, despite the virtual absence of circulating inflammatory monocytes. We performed a time course study in mice with hematopoietic and global CCR2 deficiency to determine adipose tissue-specific mechanisms for the delayed impact of CCR2 deficiency on insulin resistance.
- Publication
Diabetes, 2011, Vol 60, Issue 11, p2820
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db11-0314