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- Title
Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity.
- Authors
Prawitt, Janne; Abdelkarim, Mouaadh; Stroeve, Johanna H M; Popescu, Iuliana; Duez, Helene; Velagapudi, Vidya R; Dumont, Julie; Bouchaert, Emmanuel; van Dijk, Theo H; Lucas, Anthony; Dorchies, Emilie; Daoudi, Mehdi; Lestavel, Sophie; Gonzalez, Frank J; Oresic, Matej; Cariou, Bertrand; Kuipers, Folkert; Caron, Sandrine; Staels, Bart
- Abstract
Bile acids (BA) participate in the maintenance of metabolic homeostasis acting through different signaling pathways. The nuclear BA receptor farnesoid X receptor (FXR) regulates pathways in BA, lipid, glucose, and energy metabolism, which become dysregulated in obesity. However, the role of FXR in obesity and associated complications, such as dyslipidemia and insulin resistance, has not been directly assessed.
- Publication
Diabetes, 2011, Vol 60, Issue 7, p1861
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db11-0030