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- Title
Uncoupling of proliferation and cytokines from suppression within the CD4+CD25+Foxp3+ T-cell compartment in the 1st year of human type 1 diabetes.
- Authors
Hughson, Angela; Bromberg, Irina; Johnson, Barbara; Quataert, Sally; Jospe, Nicholas; Fowell, Deborah J
- Abstract
The mechanistic basis for the breakdown of T-cell tolerance in type 1 diabetes is unclear and could result from a gain of effector function and/or loss of regulatory function. In humans, the CD4+CD25+Foxp3+ T-cell compartment contains both effector and regulatory T cells, and it is not known how their relative proportions vary in disease states.
- Publication
Diabetes, 2011, Vol 60, Issue 8, p2125
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db10-1661