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- Title
Altered skeletal muscle lipase expression and activity contribute to insulin resistance in humans.
- Authors
Badin, Pierre-Marie; Louche, Katie; Mairal, Aline; Liebisch, Gerhard; Schmitz, Gerd; Rustan, Arild C; Smith, Steven R; Langin, Dominique; Moro, Cedric
- Abstract
Insulin resistance is associated with elevated content of skeletal muscle lipids, including triacylglycerols (TAGs) and diacylglycerols (DAGs). DAGs are by-products of lipolysis consecutive to TAG hydrolysis by adipose triglyceride lipase (ATGL) and are subsequently hydrolyzed by hormone-sensitive lipase (HSL). We hypothesized that an imbalance of ATGL relative to HSL (expression or activity) may contribute to DAG accumulation and insulin resistance.
- Publication
Diabetes, 2011, Vol 60, Issue 6, p1734
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db10-1364