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- Title
Genetic defects in human pericentrin are associated with severe insulin resistance and diabetes.
- Authors
Huang-Doran, Isabel; Bicknell, Louise S; Finucane, Francis M; Rocha, Nuno; Porter, Keith M; Tung, Y C Loraine; Szekeres, Ferenc; Krook, Anna; Nolan, John J; O'Driscoll, Mark; Bober, Michael; O'Rahilly, Stephen; Jackson, Andrew P; Semple, Robert K; Majewski Osteodysplastic Primordial Dwarfism Study Group
- Abstract
Genetic defects in human pericentrin (PCNT), encoding the centrosomal protein pericentrin, cause a form of osteodysplastic primordial dwarfism that is sometimes reported to be associated with diabetes. We thus set out to determine the prevalence of diabetes and insulin resistance among patients with PCNT defects and examined the effects of pericentrin depletion on insulin action using 3T3-L1 adipocytes as a model system.
- Publication
Diabetes, 2011, Vol 60, Issue 3, p925
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db10-1334