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- Title
Glucose and inflammation control islet vascular density and beta-cell function in NOD mice: control of islet vasculature and vascular endothelial growth factor by glucose.
- Authors
Akirav, Eitan M; Baquero, Maria-Teresa; Opare-Addo, Lynn W; Akirav, Michael; Galvan, Eva; Kushner, Jake A; Rimm, David L; Herold, Kevan C
- Abstract
β-Cell and islet endothelial cell destruction occurs during the progression of type 1 diabetes, but, paradoxically, β-cell proliferation is increased during this period. Altered glucose tolerance may affect β-cell mass and its association with endothelial cells. Our objective was to study the effects of glucose and inflammation on islet vascularity and on β function, mass, and insulin in immunologically tolerant anti-CD3 monoclonal antibody (mAb)-treated and prediabetic NOD mice.
- Publication
Diabetes, 2011, Vol 60, Issue 3, p876
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db10-0793