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- Title
Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis.
- Authors
Huang, Jingyu; Jones, Deborah; Luo, Bai; Sanderson, Michael; Soto, Jamie; Abel, E Dale; Cooksey, Robert C; McClain, Donald A
- Abstract
Excess tissue iron levels are a risk factor for diabetes, but the mechanisms underlying the association are incompletely understood. We previously published that mice and humans with a form of hereditary iron overload, hemochromatosis, exhibit loss of β-cell mass. This effect by itself is not sufficient, however, to fully explain the diabetes risk phenotype associated with all forms of iron overload.
- Publication
Diabetes, 2011, Vol 60, Issue 1, p80
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db10-0593